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LGD 4033 was developed with the goal of preventing muscle loss in the elderly and in those who suffer from muscle dystrophy(MD). It is widely believed that MD develops slowly and that the elderly are predisposed. Thus, this program has focused on the prevention of MD and not on the preservation of muscle mass in elderly patients and persons with MD. This program, however, does not require caloric restriction, either before or during and/or after any exercise program. Rather, it encourages the patient to eat a diet that is balanced, protein-rich, and high in fiber as well as lean muscle mass. Diet and Exercise In addition to aerobic exercise, patients can perform resistance training. In the diet and exercise group, both exercises and diets were performed before and immediately after exercise to promote the maintenance of muscle mass. In these two groups, carbohydrate consumption in the diet group (25%) was increased as compared to the exercise group (10%). The goal was to maintain the carbohydrate balance of 4-6 g per kg dietary protein and 1-2 g per kg fat. In addition, as mentioned above, both the exercise and diet diets were given to patients at least 6 weeks prior to their exercise sessions. The diet and exercise group received a total of 16 servings of an egg whites and 6-8 servings of an egg yolk containing 1 gram of protein and 6 grams of fat. After training, patients took an electrolyte beverage and a protein shake as well as a protein powder. After the 6 weeks after training, patients were asked to stop their exercise to avoid muscle soreness that may develop. Dietary Supplementation The diet and exercise group received all dietary supplements included in the American Journal of Clinical Nutrition guidelines at the time of testing, but in the diet group they were provided with soy protein isolate as well as a zinc sulfate. Outcome Measures The primary outcome measure was change in muscle mass, which was defined as the change in mean body weight divided by the mean number of kilograms of muscle mass. Secondary outcomes included the following: muscle strength and endurance capacity (defined as the number of bench press repetitions from 40 to 180 or 60 to 240 in the single leg squat), the percentage change of body mass and changes in muscle strength and endurance. The percentage change in muscle strength and endurance capacity was calculated as the percentage change of lean body mass from a baseline body weight of 130 to 150. Statistical Analyses Data were analyzed with the use of SPSS for Windows for Excel 2003 (version 8.0; SPSS Inc, Chicago, IL). All Related Article:

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